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portada Necrotic Cell Death (Cell Death in Biology and Diseases)
Type
Physical Book
Publisher
Author
Language
English
Pages
411
Format
Paperback
ISBN13
9781493944026
Edition No.
1

Necrotic Cell Death (Cell Death in Biology and Diseases)

Shen Han-Ming|Vandenabeele Peter (Author) · Humana · Paperback

Necrotic Cell Death (Cell Death in Biology and Diseases) - Shen Han-Ming|Vandenabeele Peter

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Synopsis "Necrotic Cell Death (Cell Death in Biology and Diseases)"

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

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