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portada controlled genetic manipulations
Type
Physical Book
Illustrated by
Publisher
Author
Language
English
Pages
309
Format
Hardcover
Dimensions
25.4x18.3x2 cm
Weight
0.61 kg.
ISBN
1617795321
ISBN13
9781617795329
Categories

controlled genetic manipulations

Alexei Morozov (Illustrated by) · Humana · Hardcover

controlled genetic manipulations - Morozov, Alexei

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Synopsis "controlled genetic manipulations"

The current demand for the development of techniques for controlled genetic manipulations is driven by the anatomical and physiological complexity of the brain and by the need for experimental models that can address this complexity through selective manipulation of defined components of the system: specific neuronal populations or selected synapses. In Controlled Genetic Manipulations, expert researchers present detailed chapters to supply basic technical information about controlled genetic manipulations and to provide examples of creative implementation of this methodology when addressing a unique biological problem. Some chapters of the book describe the most recent developments in the basic methodology, which includes use of Cre-recombinase, methods for delivery of genetic material into the brain and the use of optogenetics, whereas other chapters focus on applying these techniques to addressing particular biological questions like structural and functional mapping of neuronal circuits, analysis of specific synaptic connections, modeling or gene therapy of neurological disorders. As part of the Neuromethods series, chapters include key implementation advice that is crucial for getting optimal results. Authoritative and practical, Controlled Genetic Manipulations serves as a valuable guide to a variety of techniques, provided by many of the pioneers of the approaches.

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