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portada Coumarin Derivatives
Type
Physical Book
Author
Publisher
Language
English
Pages
92
Format
Paperback
Dimensions
22.9x15.2x0.6 cm
Weight
0.15 kg.
ISBN13
9786202564151
Categories

Coumarin Derivatives

Nachiket Dighe (Author) · Sanjay Bhawar (Author) · LAP Lambert Academic Publishing · Paperback

Coumarin Derivatives - Dighe, Nachiket ; Bhawar, Sanjay

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Delivery: 13 Nov - 23 Nov Shipping: 14 to 15 business days.
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Synopsis "Coumarin Derivatives"

The present research work deals with the synthesis, characterisation and to evaluate the synthesized compound for antidepressant activity of a series of coumarin derivatives. Basic coumarin is prepared by Perkin reaction, which further reacted with aryl thiourea by cyclization reaction leads to produce 3-(2-(phenylaminothiazol-4-yl)-2H-chromen-2-one. Totally twelve compounds, were synthesized by conventional method and their purity was determined by TLC and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A4, A5 and A9) showed significant antidepressant activity comparing with control drug imipramine and some compound shows mild antidepressant activity. These results are useful for the further investigation in the future.

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