Name: Development of Memory - B Cells
SKU: 57630494
Price: 1502.00 TWD
Availability: InStock
Author: K. K., Prakash ; B. M., Santhosh
ISBN: 9786202680219

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Type

Physical Book

Author

Prakash K. K.

Santhosh B. M.

Publisher

LAP Lambert Academic Publishing

Language

English

Pages

Format

Paperback

Dimensions

22.9x15.2x0.4 cm

Weight

0.10 kg.

ISBN13

9786202680219

Synopsis "Development of Memory - B Cells"

Naive B cells and somatically mutated memory cells are produced by a process involving cell proliferation accompanied by stringent cellular selection, so that only cells of the desired phenotype survive. In both processes there is positive selection, first of cells with an in frame VHDHJH rearrangement, which can thus express a p-chain in the pBCR; then of B cells expressing a complete antibody in a functional receptor complex, presumably through expression of the BCR; and finally of somatic mutants expressing high-affinity antibodies in their BCR in the germinal center reaction. Only in the last case do we know the ligand that drives the selection; at earlier stages, selection may be driven by ligands on cells in the environment or by cell-autonomous mechanisms. In all cases, however, unselected cells are rapidly lost from the system, presumably by apoptosis.

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Development of Memory - B Cells - K. K., Prakash ; B. M., Santhosh

Synopsis "Development of Memory - B Cells"

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