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portada folates and cobalamins
Type
Physical Book
Illustrated by
Publisher
Author
Year
1989
Language
English
Pages
264
Format
Paperback
Dimensions
24.2x17.3x1.6 cm
Weight
0.48 kg.
ISBN
3540506535
ISBN13
9783540506539
Categories

folates and cobalamins

Jaqueline A. Zittoun (Illustrated by) · Bernard A. Cooper (Illustrated by) · Springer · Paperback

folates and cobalamins - Zittoun, Jaqueline A. ; Cooper, Bernard A.

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Synopsis "folates and cobalamins"

It is usual to associate megaloblastic anemia with folate or cobalamin deficien cies. However, this notion, even if true in most cases, is too restricted. Megalo blastosis in blood may also be observed in blood diseases without vitamin defi ciency, and also after treatment with certain antineoplastic agents; in these con ditions, the mechanisms vary with the etiology. On the other hand, folate or cobalamin deficiency may induce various clinical or biochemical disturbances without - as yet - macrocytic megaloblastic anemia. That the biochemical basis of megaloblastosis is the same in folate and cobal amin deficiencies is due to the close metabolic interrelationships between thse two vitamins. However, the role of cobalamin deficiency in folate metabolism is still a matter of debate. Morphological abnormalities such as macrocytosis in peripheral blood and megablastosis in bone marrow, long considered to be the best indices of vitamin deficiency, are not always constant. Indeed, the improved diagnostic methods often lead to an early diagnosis of deficiency before the appearance of the usual hematological abnormalities."

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