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portada gap junctions in development and disease
Type
Physical Book
Illustrated by
Publisher
Author
Year
2005
Language
English
Pages
279
Format
Hardcover
Dimensions
23.4x15.6x1.8 cm
Weight
0.59 kg.
ISBN
3540261567
ISBN13
9783540261568
Categories

gap junctions in development and disease

Elke Winterhager (Illustrated by) · Springer · Hardcover

gap junctions in development and disease - Winterhager, Elke

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Synopsis "gap junctions in development and disease"

Communication between cells via intercellular channels - gap junctions - appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

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