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portada Novel Anticancer Drug Protocols
Type
Physical Book
Publisher
Author
Language
English
Pages
355
Format
Paperback
Dimensions
22.9 x 15.2 x 2.0 cm
Weight
0.52 kg.
ISBN13
9781489938398
Categories

Novel Anticancer Drug Protocols

Buolamwini, John K. ; Adjei, Alex A. (Author) · Humana · Paperback

Novel Anticancer Drug Protocols - Buolamwini, John K. ; Adjei, Alex A.

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Synopsis "Novel Anticancer Drug Protocols"

We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin(R) (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.

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