Name: Oligonucleotide, Therapy, and Applications
SKU: 56772328
Price: 1487.00 TWD
Availability: InStock
Author: Aliño, Salvador F. ; Sendra, Luis
ISBN: 9783036530574

portada Oligonucleotide, Therapy, and Applications

Oligonucleotide, Therapy, and Applications

Type

Physical Book

Publisher

Mdpi AG

Author

Aliño, Salvador F. ; Sendra, Luis

Language

English

Pages

126

Format

Hardcover

Dimensions

24.4x17x1.3 cm

Weight

0.48 kg.

ISBN13

9783036530574

Synopsis "Oligonucleotide, Therapy, and Applications"

Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice. In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs.

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Oligonucleotide, Therapy, and Applications - Aliño, Salvador F. ; Sendra, Luis

Synopsis "Oligonucleotide, Therapy, and Applications"

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