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portada clostridium difficile
clostridium difficileclostridium difficile
Type
Physical Book
Publisher
Language
English
Pages
143
ISBN
3540672915
ISBN13
9783540672913
Categories

clostridium difficile

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Synopsis "clostridium difficile"

clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. this volume gives new insights into the microbiology, diagnostics and epidemiology of clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. main parts of the volume are devoted to clostridium difficile toxins a and b which are the major virulence factors. the molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. clostridium difficile toxins act as glucosyltransferases to inactivate small gtp-binding proteins of the rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

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