Name: Screening for Biological Response Modifiers: Methods and Rationale
Price: 3810.00 TWD
Availability: InStock
Author: Talmadge, James E. ; Fidler, Isaiah J. ; Oldham, R. K.
ISBN: 9781461296249

portada Screening for Biological Response Modifiers: Methods and Rationale

Screening for Biological Response Modifiers: Methods and Rationale

Type

Physical Book

Author

Publisher

Language

English

Pages

194

Format

Paperback

Dimensions

23.4 x 15.6 x 1.1 cm

Weight

0.30 kg.

ISBN13

9781461296249

Synopsis "Screening for Biological Response Modifiers: Methods and Rationale"

The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for "screening" drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).

Customers reviews

Have you read this book? Login to add your review.

More customer reviews

0% (0)
0% (0)
0% (0)
0% (0)
0% (0)

Questions and Answers about the Book

Do you have a question about the book? Login to be able to add your own question.

Opinions about Bookdelivery

More customer reviews

Screening for Biological Response Modifiers: Methods and Rationale - Talmadge, James E. ; Fidler, Isaiah J. ; Oldham, R. K.

Synopsis "Screening for Biological Response Modifiers: Methods and Rationale"

Customers reviews

Frequently Asked Questions about the Book

Is the book original?

In what language is the book written?

What is the format of this book?

Questions and Answers about the Book

Opinions about Bookdelivery