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portada Antimalarial Natural Products
Type
Physical Book
Publisher
Author
Language
English
Pages
106
Format
Hardcover
Dimensions
23.4 x 15.6 x 0.8 cm
Weight
0.35 kg.
ISBN13
9783030898724
Categories

Antimalarial Natural Products

Kinghorn, A. Douglas ; Falk, Heinz ; Gibbons, Simon (Author) · Springer · Hardcover

Antimalarial Natural Products - Kinghorn, A. Douglas ; Falk, Heinz ; Gibbons, Simon

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Synopsis "Antimalarial Natural Products"

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

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