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portada Considering the Patient in Pediatric Drug Development: How Good Intentions Turned Into Harm
Type
Physical Book
Publisher
Author
Year
2020
Language
English
Pages
414
Format
Paperback
ISBN13
9780128238882
Edition No.
1
Categories

Considering the Patient in Pediatric Drug Development: How Good Intentions Turned Into Harm

Klaus Rose (Author) · Academic Press · Paperback

Considering the Patient in Pediatric Drug Development: How Good Intentions Turned Into Harm - Klaus Rose

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Synopsis "Considering the Patient in Pediatric Drug Development: How Good Intentions Turned Into Harm "

Considering the Patient in Pediatric Drug Development: How Good Intentions Turned into Harm addresses a fundamental challenge in drug development and healthcare for young patients. In clinical trials and clinical practice, the term "children" is used ambiguously to confer physiological characteristics to a chronological age limit, which in reality does not exist. This book outlines why the United States (US) and European Union's (EU) regulatory authorities, pediatric academia, and the pharmaceutical industry demand, support and perform pediatric drug studies, along with the key flaws of this demand that blurs the different administrative and physiological meanings of the term "child." In addition, the book covers why most pediatric regulatory studies lack medical sense and many even harm young patients and the conflicts of interest behind pediatric drug studies. It includes relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs as well as key differences between newborns, infants, older children and adolescents. Explains relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs, including key differences between newborns, infants, older children and adolescentsDiscusses historical roots of separate drug approval in officially labeled "children" and conflicts of interest in performing and publishing "pediatric" researchHelps to decipher justifications for pediatric studies to help people navigate the relevance of the information

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