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portada Current Approaches to Cryo-Electron Microscopy (Volume 223) (Progress in Molecular Biology and Translational Science, Volume 223)
Type
Physical Book
Publisher
Author
Language
English
Pages
300
Format
Hardcover
ISBN13
9780443431609

Current Approaches to Cryo-Electron Microscopy (Volume 223) (Progress in Molecular Biology and Translational Science, Volume 223)

Teplow David B. (Author) · Academic Press · Hardcover

Current Approaches to Cryo-Electron Microscopy (Volume 223) (Progress in Molecular Biology and Translational Science, Volume 223) - Teplow David B.

New Book Imported to Taiwan
Delivery: 29 Sep - 14 Oct Shipping: 54 to 60 business days.
NT$ 8,084
NT$ 8,084

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Synopsis "Current Approaches to Cryo-Electron Microscopy (Volume 223) (Progress in Molecular Biology and Translational Science, Volume 223)"

Cryo-electron microscopy (cryo-EM) has emerged as a transformative technique in structural biology, driving an exponential increase in the number of structures deposited in the Protein Data Bank. Current workflows now routinely achieve the near-atomic resolution essential for understanding the molecular pathology of neurodegenerative and metabolic disorders. This provides a comprehensive overview of the field, tracing the evolution from early structural studies to modern pipelines powered by deep-learning algorithms for helical reconstruction. We address the persistent bottleneck of sample preparation, detailing the physical challenges of fibril clumping and interfacial adsorption, alongside emerging solutions to these problems. Furthermore, we examine the complexities of structural polymorphism, discussing how environmental factors and seeding drive conformational diversity and how this heterogeneity impacts biochemical assays. Finally, we highlight the translational value of these high-resolution maps, demonstrating how they enable the rational, structure-based design of peptide inhibitors and small molecules capable of disaggregating pathogenic fibrils.

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