Name: Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology)
Price: 1064.00 TWD
Availability: InStock
Author: Kim, So Yeon ; Costa, Daniel B. ; Shibahara, Daisuke
ISBN: 9781009342308

portada Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology)

Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology)

Type

Physical Book

Author

So Yeon Kim

Daniel B. Costa

Daisuke Shibahara

Publisher

Cambridge University Press

Language

English

Pages

Format

Paperback

Dimensions

22.9 x 15.2 x 0.2 cm

Weight

0.07 kg.

ISBN13

9781009342308

Edition No.

Synopsis "Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology) "

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

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Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology) - Kim, So Yeon ; Costa, Daniel B. ; Shibahara, Daisuke

Synopsis "Egfr-Directed Therapy in Lung Cancer (Elements in Molecular Oncology) "

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