Huayna Capac (Quechua Wayna Qhapaq "splendid youth") was the eleventh Sapa Inca of the Inca Empire and sixth of the Hanan dynasty. He was the successor to Tupac Inca Yupanqui. His legitimate wife (and full-blooded sister) was Coya Cusirimay. The pair produced no male heirs, but Huayna Capac produced as many as 50 or more children with other women, including Ninan Cuyochi, Huscar, Atahualpa, Tupac Huallpa, Manco Inca Yupanqui, General Atoc, Pawllu Inca and Quispe Sisa - all of whom could be said to be his successors. Huayna Capac extended the Inca empire (Tahuantinsuyu) significantly to the south into present-day Chile and Argentina. For many years he and his armies fought to annex territories North of his empire in what is now Ecuador (and a small region of Colombia) to the northernmost province. The capital city of the empire was far to the south in Cuzco, and Huayna Capac hoped to establish a northern stronghold in the city of Quito. Huayna Capac died around 1527 on the Northern Frontier of the empire after the long-fought Quito Wars. He likely died of the smallpox epidemic that had already decimated the capital, Cuzco, though some evidence suggests Bartonellosis was to blame.