Tracked shipping to Taiwan with premium packaging for just NT$300 

Ship to
Taiwan
0

My Account

  • argentina
  • chile
  • colombia
  • españa
  • méxico
  • perú
  • estados unidos
  • internacional

menu

Select your country

Americas

Europe

Rest of the world

portada N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology
Type
Physical Book
Author
Publisher
Language
English
Pages
487
Format
Paperback
Dimensions
23.4 x 15.6 x 2.6 cm
Weight
0.71 kg.
ISBN13
9789401053785
Categories

N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology

P. Hlavica (Author) · L. a. Damani (Author) · Springer · Paperback

N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology - Hlavica, P. ; Damani, L. a.

Cheaper New Book Imported to Taiwan
Delivery: 25 Aug - 08 Sep Shipping: 12 to 16 business days.
NT$ 9,467
Faster New Book Imported to Taiwan
Delivery: 13 Aug - 21 Aug Shipping: 4 to 5 business days.
NT$ 12,605
NT$ 9,467

Choose the list to add your product or create one New List

Go to My Wishlists
Calculate shipping cost

Synopsis "N-Oxidation of Drugs: Biochemistry, Pharmacology, Toxicology"

The metabolic N-oxidation ofnitrogenousxenobiotics has been reported tc occur in many biologicalsystems, in addition to mammaliantissues, and the mechanisms appear to differ in many respects from those involved in oxidative attack atcarbon centres. Theextensive useofnitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to alarge numberofthese agentsunderwidelyvaryingconditions. Biotransformation of these xenobiotics by N-oxidative pathways can effect detoxication, butequallywellcaninduceformation ofcytotoxicmetabolites or potential promutagens and procarcinogens. The substantial progress, in recent years, in our understanding ofthe biochemistry and toxicology of N- oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book provides a wide-ranging review of the state-of-the-art in nitrogen xenobiochemistry divided into four parts. The introductory chapter discusses recent developments in trace analysis of radical intermediates and other N-oxygenated products by physical and immunochemical techniques. Special attention is given in Part Two to the enzymology of N-oxidation. Thus, detailed account is given of the mechanism and substrate specificity of the flavin-containing mono- oxygenase and factors regulating its activity are addressed. A separate chapter outlines the polymorphic expression of flavoprotein-dependent reactions. Similarly, the mechanistic background and inducibility of cytochrome P-450-catalysed turnover of specific types of nitrogenous compounds is highlighted. Data are also compiled describing the role of peroxidative N-oxidation of xenobiotics in extrahepatic tissues lacking significant amounts ofcytochrome P-450.

Customers reviews

More customer reviews
  • 0% (0)
  • 0% (0)
  • 0% (0)
  • 0% (0)
  • 0% (0)

Frequently Asked Questions about the Book

Is the book original?

All books in our catalog are Original.

In what language is the book written?

The book is written in English.

What is the format of this book?

The binding of this edition is Paperback.

Questions and Answers about the Book

Do you have a question about the book? Login to be able to add your own question.

Opinions about Bookdelivery

More customer reviews