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portada Neurobiology of Essential Fatty Acids
Type
Physical Book
Publisher
Author
Language
English
Pages
444
Format
Paperback
ISBN13
9781461365150
Categories

Neurobiology of Essential Fatty Acids

Bazan, Nicolas G. ; Murphy, Mary G. ; Toffano, Gino (Author) · Springer · Paperback

Neurobiology of Essential Fatty Acids - Bazan, Nicolas G. ; Murphy, Mary G. ; Toffano, Gino

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Synopsis "Neurobiology of Essential Fatty Acids"

It is increasingly evident that polyunsaturated fatty acids (PUFA), which in the past were often believed to be mere components of cellular membranes of neural tissue, are actually major determinants of the functional properties of neural cells and are intimately involved in brain disease processes. The two families of PUF A, which are derived from the essential polyenes, linoleic (18:26) and a-linolenic (18:33) acids, constitute a major proportion (-30%) of the total fatty acids esterified to brain phospholipids. Each family is distributed in membranes in a highly specific manner with respect to brain region, cell type, and position within each of the phosphoglycerides. Unlike their behavior in other organs, the PUF A components of brain turn over slowly and are relatively resistant to dietary modification. Their unique distribution and stability suggest that they play an important role in determining the functional properties of neural cells. However, until recently very little was known regarding the precise nature of their involvement.

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