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portada Neurotrophic Natural Products
Type
Physical Book
Publisher
Author
Language
English
Pages
473
Format
Hardcover
Dimensions
15.0 x 23.2 x 1.4 cm
Weight
0.93 kg.
ISBN13
9783031424212
Categories

Neurotrophic Natural Products

Kinghorn, A. Douglas ; Falk, Heinz ; Gibbons, Simon (Author) · Springer · Hardcover

Neurotrophic Natural Products - Kinghorn, A. Douglas ; Falk, Heinz ; Gibbons, Simon

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Synopsis "Neurotrophic Natural Products"

This book deals with neurotrophins (NGF, BDNF, NT3, NT4), which can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons. This makes neurotrophins potential therapeutic agents for the treatment of neurodegenerative disorders. However, these proteins have so far been ineffective in clinical trials mostly because they cannot pass the blood-brain barrier owing to their high-molecular weights. Consequently, small molecules that mimic neurotrophins and stimulate the synthesis of endogenous neurotrophins or enhance their neurotrophic actions are expected to be promising alternatives. Small-molecule natural products, which have been used in dietary functional foods or in traditional medicine over the course of human history, have potential to be developed as new therapeutic agents against neurodegenerative conditions such as Alzheimer's disease. In this book, the authors introduce a variety of natural products possessing neurotrophic properties such as neurogenesis, neurite outgrowth promotion (neuritogenesis), and neuroprotection and focus on the chemistry and biology of several neurotrophic natural products.

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