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portada Perinatal Fluoxetine-induced Neurofunctional Changes
Type
Physical Book
Author
Publisher
Language
English
Pages
56
Format
Paperback
Dimensions
22.9 x 15.2 x 0.3 cm
Weight
0.10 kg.
ISBN13
9786207212354
Categories

Perinatal Fluoxetine-induced Neurofunctional Changes

José Francis de Oliveira (Author) · Our Knowledge Publishing · Paperback

Perinatal Fluoxetine-induced Neurofunctional Changes - de Oliveira, José Francis

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Synopsis "Perinatal Fluoxetine-induced Neurofunctional Changes"

There is a considerable risk of developing depression during pregnancy and breastfeeding. Pharmacological treatment of depression in pregnant women is advised in several cases, and the drugs of choice are serotonin reuptake inhibitors (SSRIs), such as fluoxetine. Considering that serotonin modulates various processes during the development of the organism, the potential effects of perinatal exposure to SSRIs on neurodevelopment are being investigated. In rats, exposure to fluoxetine during the perinatal period (pregnancy and lactation) decreased decision-making capacity, but did not induce anhedonia, in adolescent males and females. In response to a stressor, there was no difference in corticosterone secretion, but adolescent males had reduced activation of the basolateral amygdala, and in adulthood this reduction occurred in the medial amygdala. This study indicates that perinatal fluoxetine exposure induces neurofunctional alterations that may be dependent on gender and age, highlighting the importance of the perinatal environment as a determinant of neurofunctional alterations that continue into adulthood.

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