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portada Cellular senescence, a multifaceted cellular state
Type
Physical Book
Author
Publisher
Language
English
Pages
52
Format
Paperback
Dimensions
22.9x15.2x0.3 cm
Weight
0.09 kg.
ISBN13
9786204133690
Categories

Cellular senescence, a multifaceted cellular state

Joe Kobakozete Zezia (Author) · Our Knowledge Publishing · Paperback

Cellular senescence, a multifaceted cellular state - Kobakozete Zezia, Joe

New Book Imported to Taiwan
Delivery: 17 Nov - 25 Nov Shipping: 14 to 15 business days.
NT$ 1,519
NT$ 1,519

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Synopsis "Cellular senescence, a multifaceted cellular state"

The aim of this book is to understand the impact that senescent cells can have on the process of remodeling of the extracellular matrix via the secretion of the secretory phenotype associated with senescence but also the consequences of this modification of the extracellular matrix on development. cancers and metastases.Different models of xenografts in vitro and in vivo in mice were used and showed a change in the level of mRNA expression of most factors associated with SASP such as IL-1α, IL-6, IL-8, MMP -1, MMP-3, MMP-10, MMP-12, VEGF etc. in senescent models compared to non-senescent models.These different factors secreted as a result of their overexpression promote excessive degradation of the extracellular matrix and chronic inflammation, the starting point for the occurrence of an epithelial-mesenchymal transition which in turn initiates the development of cancer cells.Thus, the therapeutic approach aimed at eliminating senescent cells using senolytic drugs seems to be effective during aging but also in the fight against age-related diseases associated with it.

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