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portada Cytogenetics
Type
Physical Book
Publisher
Author
Language
English
Pages
80
Format
Paperback
Dimensions
22.9x15.2x0.5 cm
ISBN13
9786208470234

Cytogenetics

Mallikarjunaiah, Shanthala; Karunyaa R., Jyoti (Author) · LAP Lambert Academic Publishing · Paperback

Cytogenetics - Mallikarjunaiah, Shanthala; Karunyaa R., Jyoti

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Synopsis "Cytogenetics"

Acute myeloid leukemia (AML) is a category of diseases with a common aggressive clinical presentation but with a poor prognosis and management that is dependent upon the underlying genetic characteristics of the neoplasm. Genetic analysis of AML is essential, and conventional karyotyping is the key factor in diagnosis and management of AML. In this study, 65952 cases were studied from the data, 251 males (63.87%) and 142 females (36.13%). The range of age in this study was 2 months to 87 years. The maximum chromosomal abnormality was observed in males compared to females, median age of 31 years. Individual karyotypes showed that total 23 types of rare cytogenetic abnormalities were recorded. The analysis of AML data showed that incidence of ph+ve chromosome, complex karyotypes, tetraploid/near tetraploid (T/NT), t(1;2)(p35;p22), t(1;3)(p36.2;p26.2) t(10;12)(p15.2;q24.11), high hyperploidy, >=49 chromosomes; tetraploidy (4n = 92 chromosomes) are marker karyotype, which were of significance. del Y or X, 9,7; Abn19q13; Trisomy22, Core binding factor (CBF) (+ve AML). The highest % incidence of individual rare abnormalities in AML patients is t(1;2)(p35;p22), t(1;3)(p36.2;p26.2) t(10;12).

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